{"slug":"ghk-cu-50mg","product":"GHK-Cu 50mg","productUrl":"https://aurex.bio/products/ghk-cu-50mg","curated":true,"cas":"89030-95-5","molecularFormula":"C₁₄H₂₃CuN₆O₄","molarMass":"402.91 g/mol","purityFloor":"≥99%","endotoxinSpec":"<1.0 EU/mg","heavyMetalsScreened":true,"mechanism":"GHK-Cu is the copper(II) complex of the endogenous tripeptide glycyl-L-histidyl-L-lysine. In vitro it acts as a high-affinity copper carrier with characterized activity on fibroblast proliferation, decorin and collagen-I/III synthesis, MMP-2 activation, and antioxidant gene expression. Pickart and colleagues have shown the Cu(II) complex modulates ~4,000 human genes toward a regenerative profile in cultured fibroblasts.","applications":[{"area":"Dermal fibroblast ECM synthesis","description":"Collagen-I, collagen-III, decorin, and elastin upregulation assays in primary human dermal fibroblast cultures.","concentrationRange":"1 nM to 10 µM"},{"area":"Wound-bed angiogenesis modeling","description":"VEGF / FGF-2 release + tube-formation assays in HUVEC + co-culture wound models.","concentrationRange":"10 nM to 1 µM"},{"area":"Hair-follicle dermal papilla proliferation","description":"BrdU incorporation + hair-shaft elongation in cultured dermal papilla cells and follicle organ explants.","concentrationRange":"0.1 µM to 10 µM"}],"synergies":[{"name":"BPC-157","rationale":"Parallel evaluation in fibroblast migration + angiogenesis pathway readouts — complementary mechanisms (NO/VEGF axis vs copper-carrier)."},{"name":"Argireline (Acetyl Hexapeptide-3)","rationale":"Pair surface-applied SNAP-25 modulator with dermal ECM-remodeling reference in skin-equivalent assays."},{"name":"Thymosin Beta-4 (TB-500 / Peptide-2 axis)","rationale":"Co-treatment in scratch-wound + actin-binding assays; shared interest in dermal regeneration pathways."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 30 days","light":"Protect from light — copper complex is photosensitive in solution","solubility":"Soluble in bacteriostatic water; reconstituted solutions exhibit a characteristic deep blue color from the Cu(II) chromophore"},"citations":[{"authors":"Pickart L, Margolina A","year":2018,"journal":"International Journal of Molecular Sciences","title":"Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data"},{"authors":"Pickart L, Vasquez-Soltero JM, Margolina A","year":2015,"journal":"Oxidative Medicine and Cellular Longevity","title":"GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration"},{"authors":"Maquart FX, et al.","year":1988,"journal":"FEBS Letters","title":"Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}