{"slug":"glow","product":"Glow","productUrl":"https://aurex.bio/products/glow","curated":true,"mechanism":"GLOW is a research-grade blend of Tirzepatide (dual GLP-1/GIP agonist, 5 mg/mL) + Retatrutide (triple GLP-1/GIP/glucagon agonist, 4 mg/mL). The combination spans the full incretin-receptor axis plus glucagon-receptor signaling, with characterized bias profiles distinct from either compound alone in cAMP-accumulation panels.","applications":[{"area":"Multi-receptor incretin signaling","description":"Simultaneous GLP-1R / GIPR / GCGR cAMP profiling in CHO cells stably expressing each receptor.","concentrationRange":"pM to nM range"},{"area":"Hepatic glucagon-axis activation","description":"GCGR-mediated cAMP + downstream gluconeogenic gene expression in HepG2 cells.","concentrationRange":"10 nM to 1 µM"},{"area":"Comparative bias profiling","description":"β-arrestin vs G-protein recruitment ratios across the receptor panel — blend vs single-agonist baselines.","concentrationRange":"nM range"}],"synergies":[{"name":"Tirzepatide (mono)","rationale":"Dual-agonist baseline for separating GIP-arm vs glucagon-arm contributions."},{"name":"Retatrutide (mono)","rationale":"Triple-agonist baseline — already in the Aurex catalog as standalone SKU."},{"name":"KLOW","rationale":"Sister blend (sema + cagri) with amylin-pathway addition — full Aurex blend comparator series."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 30 days","light":"Protect from light and air","solubility":"Soluble in bacteriostatic water (0.9% benzyl alcohol)"},"citations":[{"authors":"Coskun T, et al.","year":2018,"journal":"Molecular Metabolism","title":"LY3298176, a novel dual GIP and GLP-1 receptor agonist (Tirzepatide)"},{"authors":"Coskun T, et al.","year":2022,"journal":"Cell Metabolism","title":"LY3437943, a novel triple GIP/GLP-1/glucagon receptor agonist (Retatrutide)"},{"authors":"Jastreboff AM, et al.","year":2023,"journal":"New England Journal of Medicine","title":"Triple-Hormone-Receptor Agonist Retatrutide for Obesity"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}