{"slug":"glutathione-600mg","product":"Glutathione 600mg","productUrl":"https://aurex.bio/products/glutathione-600mg","curated":true,"cas":"70-18-8","molecularFormula":"C₁₀H₁₇N₃O₆S","molarMass":"307.32 g/mol","purityFloor":"≥99%","endotoxinSpec":"<0.5 EU/mg","heavyMetalsScreened":true,"mechanism":"Reduced L-glutathione (GSH) is the cell's primary low-molecular-weight thiol antioxidant. It directly scavenges free radicals via its thiol group, serves as cofactor for glutathione peroxidase, and conjugates xenobiotics in Phase II detoxification.","applications":[{"area":"Oxidative stress co-treatment","description":"Pre-treatment of neurons / hepatocytes / cardiomyocytes against tBHP, H₂O₂, or rotenone.","concentrationRange":"0.1 mM to 5 mM"},{"area":"Acetaminophen hepatotoxicity","description":"GSH-conjugation pathway studies in HepG2 + primary hepatocytes.","concentrationRange":"2 mM to 10 mM"},{"area":"Immunomodulation","description":"Modulation of immune cell responses in lymphocyte / macrophage cultures.","concentrationRange":"0.5 mM to 2 mM"}],"synergies":[{"name":"NAC (N-Acetylcysteine)","rationale":"Precursor comparison — NAC supplies cysteine for GSH biosynthesis."},{"name":"Alpha-Lipoic Acid","rationale":"Recycles oxidized GSSG back to GSH."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 30 days","light":"Protect from light and air","solubility":"Soluble in water — prepare fresh solutions, as GSH rapidly oxidizes in solution"},"citations":[{"authors":"Meister A, Anderson ME","year":1983,"journal":"Annual Review of Biochemistry","title":"Glutathione"},{"authors":"Sies H","year":1999,"journal":"Free Radical Biology and Medicine","title":"Glutathione and its role in cellular functions"},{"authors":"Dringen R, Hamprecht B","year":1997,"journal":"Journal of Neurochemistry","title":"Glutathione metabolism in brain"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}