{"slug":"igf-1-lr3-1mg","product":"IGF-1 LR3 1mg","productUrl":"https://aurex.bio/products/igf-1-lr3-1mg","curated":true,"cas":"946870-92-4","molecularFormula":"C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉","molarMass":"9111.5 g/mol","purityFloor":"≥98%","endotoxinSpec":"<1.0 EU/mg","heavyMetalsScreened":true,"mechanism":"IGF-1 LR3 is a recombinant analog of insulin-like growth factor 1 with an N-terminal extension and an arginine substitution at position 3. The modifications dramatically reduce IGFBP binding, increasing in-vitro receptor availability and prolonging effective half-life.","applications":[{"area":"IGF-1 receptor signaling","description":"IGF-1R phosphorylation + downstream PI3K/AKT pathway activation in C2C12 and primary myoblasts.","concentrationRange":"10 ng/mL to 100 ng/mL"},{"area":"IGFBP-independent activity","description":"Comparative binding assays vs native IGF-1 in IGFBP-rich serum models.","concentrationRange":"1 ng/mL to 100 ng/mL"},{"area":"Myoblast differentiation","description":"Myotube formation kinetics + MyoD/MyoG expression in C2C12 cultures.","concentrationRange":"5 ng/mL to 50 ng/mL"}],"synergies":[{"name":"CJC-1295/Ipamorelin","rationale":"Upstream GH-axis activation — paired evaluation of GH→IGF-1 pathway."},{"name":"PEG-MGF","rationale":"Mechanistic comparator — splice variant of IGF-1 with different receptor kinetics."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 30 days","light":"Protect from light and air","solubility":"Soluble in bacteriostatic water (0.9% benzyl alcohol)"},"citations":[{"authors":"Tomas FM, et al.","year":1993,"journal":"Journal of Endocrinology","title":"Long-R3-IGF-I biological activity"},{"authors":"Adams GR","year":2002,"journal":"Journal of Applied Physiology","title":"Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}