{"slug":"klow","product":"Klow","productUrl":"https://aurex.bio/products/klow","curated":true,"mechanism":"KLOW is a research-grade blend of Semaglutide (GLP-1 receptor agonist, 2.4 mg/mL) + Cagrilintide (long-acting amylin analog, 1.2 mg/mL). The dual-receptor combination has been characterized in vitro across GLP-1R cAMP-accumulation assays and CTR/RAMP1-3 amylin-receptor binding panels — complementary appetite + glycemic-pathway readouts.","applications":[{"area":"GLP-1 receptor signaling","description":"cAMP accumulation in CHO cells stably expressing recombinant GLP-1R; β-arrestin recruitment kinetics.","concentrationRange":"pM to nM range"},{"area":"Amylin receptor binding","description":"Comparative binding panels across CTR/RAMP1-3 amylin receptor complexes vs native amylin.","concentrationRange":"nM range"},{"area":"Adipocyte energy expenditure","description":"Mitochondrial respiration (Seahorse XF) in 3T3-L1 differentiated adipocytes — paired vs single-agonist controls.","concentrationRange":"1 nM to 100 nM"}],"synergies":[{"name":"Semaglutide (mono)","rationale":"Single-agonist baseline for receptor-bias and ligand-residency studies."},{"name":"Tirzepatide","rationale":"Comparator dual GLP-1/GIP agonist — complementary mechanism panel."},{"name":"Retatrutide","rationale":"Triple GLP-1/GIP/glucagon agonist — extends the comparator series."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 30 days","light":"Protect from light and air","solubility":"Soluble in bacteriostatic water (0.9% benzyl alcohol)"},"citations":[{"authors":"Lau J, et al.","year":2015,"journal":"Journal of Medicinal Chemistry","title":"Discovery of the once-weekly GLP-1 analogue Semaglutide"},{"authors":"Lutz TA","year":2010,"journal":"Endocrine Reviews","title":"The role of amylin in the control of energy homeostasis"},{"authors":"Lau DCW, et al.","year":2021,"journal":"The Lancet","title":"Once-weekly cagrilintide for weight management"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}