{"slug":"mots-c-40mg","product":"MOTS-c 40mg","productUrl":"https://aurex.bio/products/mots-c-40mg","curated":true,"cas":"1627580-64-6","molecularFormula":"C₁₀₀H₁₅₁N₂₃O₂₂S₂","molarMass":"2174.6 g/mol","purityFloor":"≥98%","endotoxinSpec":"<1.0 EU/mg","heavyMetalsScreened":true,"mechanism":"MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene. In vitro it activates AMPK signaling and translocates to the nucleus under metabolic stress to regulate adaptive nuclear gene expression.","applications":[{"area":"AMPK pathway activation","description":"Phospho-AMPK Western blot assays in C2C12 myotubes and HepG2 cells.","concentrationRange":"0.5 µM to 10 µM"},{"area":"Insulin sensitivity modeling","description":"GLUT4 translocation + 2-deoxyglucose uptake in insulin-resistant cell models.","concentrationRange":"1 µM to 5 µM"},{"area":"Mitochondrial biogenesis","description":"PGC-1α expression + mitochondrial copy-number quantification.","concentrationRange":"1 µM to 10 µM"}],"synergies":[{"name":"NAD+ / nicotinamide riboside","rationale":"Parallel evaluation of mitochondrial-energetics readouts."},{"name":"SS-31 (Elamipretide)","rationale":"Distinct mitochondrial-targeting mechanisms — useful comparator in respiration assays."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 30 days","light":"Protect from light and air","solubility":"Soluble in bacteriostatic water (0.9% benzyl alcohol)"},"citations":[{"authors":"Lee C, et al.","year":2015,"journal":"Cell Metabolism","title":"The mitochondrial-derived peptide MOTS-c regulates metabolic homeostasis"},{"authors":"Kim KH, et al.","year":2018,"journal":"Cell Metabolism","title":"The mitochondrial-derived peptide MOTS-c translocates to the nucleus"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}