{"slug":"nad-1000mg-buffered","product":"NAD+ 1000mg (buffered)","productUrl":"https://aurex.bio/products/nad-1000mg-buffered","curated":true,"cas":"53-84-9","molecularFormula":"C₂₁H₂₇N₇O₁₄P₂","molarMass":"663.43 g/mol","purityFloor":"≥99%","endotoxinSpec":"<0.5 EU/mg","heavyMetalsScreened":true,"mechanism":"NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to redox biology and a substrate for sirtuins (SIRT1–7), PARPs, and CD38. The buffered form maintains stability at physiological pH for cell-culture supplementation.","applications":[{"area":"Sirtuin activation studies","description":"SIRT1/SIRT3 deacetylase activity assays + downstream substrate (FOXO, p53) acetylation Westerns.","concentrationRange":"100 µM to 1 mM"},{"area":"PARP-1 activity modulation","description":"DNA-damage models with PARP-1 cleavage / NAD+ depletion readouts.","concentrationRange":"50 µM to 500 µM"},{"area":"Redox state measurement","description":"NAD+/NADH ratio quantification in mitochondrial respiration assays.","concentrationRange":"100 µM to 2 mM"}],"synergies":[{"name":"MOTS-c","rationale":"Parallel mitochondrial-energetics readouts."},{"name":"Resveratrol / NMN","rationale":"Sirtuin-pathway agonist comparators."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 14 days (NAD+ oxidizes in solution)","light":"Protect from light and air","solubility":"Soluble in bacteriostatic water; prepare fresh aliquots for each experiment"},"citations":[{"authors":"Houtkooper RH, et al.","year":2012,"journal":"Endocrine Reviews","title":"NAD+ in cellular metabolism and disease"},{"authors":"Imai S, Guarente L","year":2014,"journal":"Trends in Cell Biology","title":"NAD+ and sirtuins in aging"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}