{"slug":"retatrutide-20mg","product":"Retatrutide 20mg","productUrl":"https://aurex.bio/products/retatrutide-20mg","curated":true,"cas":"2381089-83-2","molecularFormula":"C₂₂₁H₃₄₃FN₅₁O₆₅","molarMass":"4731.4 g/mol","purityFloor":"≥99%","endotoxinSpec":"<1.0 EU/mg","heavyMetalsScreened":true,"mechanism":"Retatrutide is an investigational triple-agonist peptide targeting GLP-1, GIP, and glucagon receptors simultaneously. In vitro it activates all three receptors with sub-nanomolar potency in cAMP-accumulation assays, with characterized bias profiles distinct from dual-agonist Tirzepatide.","applications":[{"area":"GLP-1/GIP/glucagon receptor signaling","description":"cAMP accumulation + β-arrestin recruitment assays in CHO cells stably expressing each receptor.","concentrationRange":"pM to nM range"},{"area":"Adipocyte lipolysis modeling","description":"Comparative lipolysis assays in 3T3-L1 differentiated adipocytes vs Tirzepatide.","concentrationRange":"1 nM to 100 nM"},{"area":"Hepatic energy expenditure","description":"Mitochondrial respiration (Seahorse XF) measurements in HepG2 hepatocytes.","concentrationRange":"10 nM to 1 µM"}],"synergies":[{"name":"Tirzepatide","rationale":"Side-by-side dual vs triple agonist comparison in receptor activation panels."},{"name":"Semaglutide","rationale":"Single-agonist baseline for receptor-bias and ligand-residency studies."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 30 days","light":"Protect from light and air","solubility":"Soluble in bacteriostatic water (0.9% benzyl alcohol)"},"citations":[{"authors":"Coskun T, et al.","year":2022,"journal":"Cell Metabolism","title":"LY3437943, a novel triple GIP/GLP-1/glucagon receptor agonist"},{"authors":"Jastreboff AM, et al.","year":2023,"journal":"New England Journal of Medicine","title":"Triple-Hormone-Receptor Agonist Retatrutide for Obesity"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}