{"slug":"semax-10mg","product":"Semax 10mg","productUrl":"https://aurex.bio/products/semax-10mg","curated":true,"mechanism":"Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-7) modified with a Pro-Gly-Pro extension. In vitro it modulates BDNF/NGF expression and has nootropic activity in cortical neuron cultures.","applications":[{"area":"BDNF / NGF expression","description":"qPCR + ELISA assays in primary cortical neuron cultures.","concentrationRange":"100 nM to 10 µM"},{"area":"Glutamate receptor modulation","description":"AMPA/NMDA receptor sensitivity assays in hippocampal slice preparations.","concentrationRange":"1 µM to 100 µM"}],"synergies":[{"name":"Selank","rationale":"Adjacent ACTH-derived nootropic peptide with anxiolytic profile."},{"name":"Cerebrolysin","rationale":"Comparator for neurotrophic-factor upregulation studies."}],"storage":{"lyophilizedTemp":"−20°C or below, desiccated","reconstitutedTemp":"2–8°C, use within 30 days","light":"Protect from light and air","solubility":"Soluble in bacteriostatic water (0.9% benzyl alcohol)"},"citations":[{"authors":"Dolotov OV, et al.","year":2006,"journal":"Journal of Neurochemistry","title":"Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression"}],"disclaimer":"Reference data is supplied for in-vitro literature context only. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Not for human or veterinary use. Not FDA approved."}