# GHK-Cu 50mg

> Copper-binding tripeptide. Wound-healing + ECM remodeling reference standard.

Canonical PDP: https://aurex.bio/products/ghk-cu-50mg
Research-data API: https://aurex.bio/api/research-data/ghk-cu-50mg

## Catalog facts
- Name: GHK-Cu (Glycyl-Histidyl-Lysyl Copper Tripeptide-1)
- SKU: `GHKCU50`
- Category: aesthetic
- Dosage: 50 mg
- Vials per kit: 1
- Total mass: 50 mg
- Half-life: ~2-4 hours (SC, free peptide)
- Reconstitution: 1 mL bacteriostatic water

## Pricing
- One-time: $65 (MSRP $95 · list $79)
- Subscribe & save: $58.50
- Stack-tier floor (3+ vials in cart): $52
- Crypto checkout (BTC, ETH, USDC, USDT, LTC): -8% across cart
- Free tracked US shipping at $200+ subtotal, otherwise $18 flat

## Stock
- Current: OUT OF STOCK — restock notify available on PDP
- Inbound from MKM: ETA Q3 2026

## Pitch
Endogenous copper-binding tripeptide (Gly-His-Lys) complexed with Cu(II). Researched for fibroblast-driven ECM remodeling, dermal collagen + decorin upregulation, and wound-bed angiogenic signaling.

## Mechanism
GHK-Cu is the copper(II) complex of the endogenous tripeptide glycyl-L-histidyl-L-lysine. In vitro it acts as a high-affinity copper carrier with characterized activity on fibroblast proliferation, decorin and collagen-I/III synthesis, MMP-2 activation, and antioxidant gene expression. Pickart and colleagues have shown the Cu(II) complex modulates ~4,000 human genes toward a regenerative profile in cultured fibroblasts.

## Common in-vitro applications
### Dermal fibroblast ECM synthesis
Collagen-I, collagen-III, decorin, and elastin upregulation assays in primary human dermal fibroblast cultures.
Working range: `1 nM to 10 µM`

### Wound-bed angiogenesis modeling
VEGF / FGF-2 release + tube-formation assays in HUVEC + co-culture wound models.
Working range: `10 nM to 1 µM`

### Hair-follicle dermal papilla proliferation
BrdU incorporation + hair-shaft elongation in cultured dermal papilla cells and follicle organ explants.
Working range: `0.1 µM to 10 µM`

## Researchers commonly co-treat with
- **BPC-157** — Parallel evaluation in fibroblast migration + angiogenesis pathway readouts — complementary mechanisms (NO/VEGF axis vs copper-carrier).
- **Argireline (Acetyl Hexapeptide-3)** — Pair surface-applied SNAP-25 modulator with dermal ECM-remodeling reference in skin-equivalent assays.
- **Thymosin Beta-4 (TB-500 / Peptide-2 axis)** — Co-treatment in scratch-wound + actin-binding assays; shared interest in dermal regeneration pathways.

## Storage and handling
- Lyophilized: −20°C or below, desiccated
- Reconstituted: 2–8°C, use within 30 days
- Light + air: Protect from light — copper complex is photosensitive in solution
- Solubility: Soluble in bacteriostatic water; reconstituted solutions exhibit a characteristic deep blue color from the Cu(II) chromophore

## Selected peer-reviewed citations
- Pickart L, Margolina A (2018). Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. *International Journal of Molecular Sciences*.
- Pickart L, Vasquez-Soltero JM, Margolina A (2015). GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. *Oxidative Medicine and Cellular Longevity*.
- Maquart FX, et al. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu²⁺. *FEBS Letters*.

## Verification
- Independently re-tested at Janoshik Analytical (HPLC-UV at 214 nm + ESI mass spectrometry).
- 100% purity-replacement guarantee: any batch failing an independent retest gets reshipped free.
- Per-batch QR code on the outer kit card resolves to https://aurex.bio/research/batch/[id].

## Compliance
Aurex is a chemical supplier and is **not** a compounding pharmacy or an outsourcing facility as defined under the Federal Food, Drug, and Cosmetic Act. Aurex products are not pharmaceuticals, food additives, or dietary supplements. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Distributed strictly for in-vitro laboratory research by qualified researchers 21+. Not for human or veterinary use. Not FDA approved.

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Generated 2026-05-04