# Klow

> Four-peptide single-vial healing blend.

Canonical PDP: https://aurex.bio/products/klow
Research-data API: https://aurex.bio/api/research-data/klow

## Catalog facts
- Name: Klow
- SKU: `BBK80`
- Category: healing
- Dosage: 80mg
- Vials per kit: 1
- Total mass: 80mg
- Half-life: varies — composite stack
- Reconstitution: 3ml bacteriostatic water per vial

## Pricing
- One-time: $120 (MSRP $159.97 · list $139.97)
- Subscribe & save: $108
- Stack-tier floor (3+ vials in cart): $96
- Crypto checkout (BTC, ETH, USDC, USDT, LTC): -8% across cart
- Free tracked US shipping at $200+ subtotal, otherwise $18 flat

## Stock
- Current: 10 vials

## Pitch
Aurex flagship recovery blend — one lyophilized vial. BPC-157 10mg + GHK-Cu 50mg + TB-500 10mg + KPV 10mg co-formulated and lyophilized together for combined tissue, vascular, and inflammatory pathway research.

## Mechanism
KLOW is a research-grade blend of Semaglutide (GLP-1 receptor agonist, 2.4 mg/mL) + Cagrilintide (long-acting amylin analog, 1.2 mg/mL). The dual-receptor combination has been characterized in vitro across GLP-1R cAMP-accumulation assays and CTR/RAMP1-3 amylin-receptor binding panels — complementary appetite + glycemic-pathway readouts.

## Common in-vitro applications
### GLP-1 receptor signaling
cAMP accumulation in CHO cells stably expressing recombinant GLP-1R; β-arrestin recruitment kinetics.
Working range: `pM to nM range`

### Amylin receptor binding
Comparative binding panels across CTR/RAMP1-3 amylin receptor complexes vs native amylin.
Working range: `nM range`

### Adipocyte energy expenditure
Mitochondrial respiration (Seahorse XF) in 3T3-L1 differentiated adipocytes — paired vs single-agonist controls.
Working range: `1 nM to 100 nM`

## Researchers commonly co-treat with
- **Semaglutide (mono)** — Single-agonist baseline for receptor-bias and ligand-residency studies.
- **Tirzepatide** — Comparator dual GLP-1/GIP agonist — complementary mechanism panel.
- **Retatrutide** — Triple GLP-1/GIP/glucagon agonist — extends the comparator series.

## Storage and handling
- Lyophilized: −20°C or below, desiccated
- Reconstituted: 2–8°C, use within 30 days
- Light + air: Protect from light and air
- Solubility: Soluble in bacteriostatic water (0.9% benzyl alcohol)

## Selected peer-reviewed citations
- Lau J, et al. (2015). Discovery of the once-weekly GLP-1 analogue Semaglutide. *Journal of Medicinal Chemistry*.
- Lutz TA (2010). The role of amylin in the control of energy homeostasis. *Endocrine Reviews*.
- Lau DCW, et al. (2021). Once-weekly cagrilintide for weight management. *The Lancet*.

## Bundled in research stacks
- [The Flagship — Aurex Elite](https://aurex.bio/stacks/flagship-bundle) — $1,299.97

## Verification
- Independently re-tested at Janoshik Analytical (HPLC-UV at 214 nm + ESI mass spectrometry).
- 100% purity-replacement guarantee: any batch failing an independent retest gets reshipped free.
- Per-batch QR code on the outer kit card resolves to https://aurex.bio/research/batch/[id].

## Compliance
Aurex is a chemical supplier and is **not** a compounding pharmacy or an outsourcing facility as defined under the Federal Food, Drug, and Cosmetic Act. Aurex products are not pharmaceuticals, food additives, or dietary supplements. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Distributed strictly for in-vitro laboratory research by qualified researchers 21+. Not for human or veterinary use. Not FDA approved.

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