# MOTS-c 40mg

> Mitochondrial-derived peptide.

Canonical PDP: https://aurex.bio/products/mots-c-40mg
Research-data API: https://aurex.bio/api/research-data/mots-c-40mg

## Catalog facts
- Name: MOTS-c
- SKU: `MS40`
- Category: longevity
- Dosage: 40mg
- Vials per kit: 1
- Total mass: 40mg
- Half-life: ~30 minutes (SC)
- Reconstitution: 2ml bacteriostatic water → 20mg/ml

## Pricing
- One-time: $108 (MSRP $139.97 · list $119.97)
- Subscribe & save: $97.20
- Stack-tier floor (3+ vials in cart): $86.40
- Crypto checkout (BTC, ETH, USDC, USDT, LTC): -8% across cart
- Free tracked US shipping at $200+ subtotal, otherwise $18 flat

## Stock
- Current: 10 vials

## Pitch
Mitochondrial-encoded 16-amino-acid peptide. Researched for AMPK activation, metabolic homeostasis, and mitochondrial-nuclear signaling pathways.

## Mechanism
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene. In vitro it activates AMPK signaling and translocates to the nucleus under metabolic stress to regulate adaptive nuclear gene expression.

## Common in-vitro applications
### AMPK pathway activation
Phospho-AMPK Western blot assays in C2C12 myotubes and HepG2 cells.
Working range: `0.5 µM to 10 µM`

### Insulin sensitivity modeling
GLUT4 translocation + 2-deoxyglucose uptake in insulin-resistant cell models.
Working range: `1 µM to 5 µM`

### Mitochondrial biogenesis
PGC-1α expression + mitochondrial copy-number quantification.
Working range: `1 µM to 10 µM`

## Researchers commonly co-treat with
- **NAD+ / nicotinamide riboside** — Parallel evaluation of mitochondrial-energetics readouts.
- **SS-31 (Elamipretide)** — Distinct mitochondrial-targeting mechanisms — useful comparator in respiration assays.

## Storage and handling
- Lyophilized: −20°C or below, desiccated
- Reconstituted: 2–8°C, use within 30 days
- Light + air: Protect from light and air
- Solubility: Soluble in bacteriostatic water (0.9% benzyl alcohol)

## Selected peer-reviewed citations
- Lee C, et al. (2015). The mitochondrial-derived peptide MOTS-c regulates metabolic homeostasis. *Cell Metabolism*.
- Kim KH, et al. (2018). The mitochondrial-derived peptide MOTS-c translocates to the nucleus. *Cell Metabolism*.

## Bundled in research stacks
- [The Longevity Stack](https://aurex.bio/stacks/longevity-stack) — $329.97
- [The Flagship — Aurex Elite](https://aurex.bio/stacks/flagship-bundle) — $1,299.97

## Verification
- Independently re-tested at Janoshik Analytical (HPLC-UV at 214 nm + ESI mass spectrometry).
- 100% purity-replacement guarantee: any batch failing an independent retest gets reshipped free.
- Per-batch QR code on the outer kit card resolves to https://aurex.bio/research/batch/[id].

## Compliance
Aurex is a chemical supplier and is **not** a compounding pharmacy or an outsourcing facility as defined under the Federal Food, Drug, and Cosmetic Act. Aurex products are not pharmaceuticals, food additives, or dietary supplements. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Distributed strictly for in-vitro laboratory research by qualified researchers 21+. Not for human or veterinary use. Not FDA approved.

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