# NAD+ 1000mg (buffered)

> High-dose buffered NAD+ — single vial.

Canonical PDP: https://aurex.bio/products/nad-1000mg-buffered
Research-data API: https://aurex.bio/api/research-data/nad-1000mg-buffered

## Catalog facts
- Name: NAD+
- SKU: `NJ1K`
- Category: longevity
- Dosage: 1000mg
- Vials per kit: 1
- Total mass: 1000mg
- Half-life: varies — IV / SC protocols
- Reconstitution: 10ml bacteriostatic water per vial

## Pricing
- One-time: $58 (MSRP $89.97 · list $67.97)
- Subscribe & save: $52.20
- Stack-tier floor (3+ vials in cart): $46.40
- Crypto checkout (BTC, ETH, USDC, USDT, LTC): -8% across cart
- Free tracked US shipping at $200+ subtotal, otherwise $18 flat

## Stock
- Current: 10 vials

## Pitch
Nicotinamide adenine dinucleotide — buffered formulation, 1000mg per vial. Researched for mitochondrial NAD+/NADH ratio, sirtuin signaling, and cellular energetics pathways.

## Mechanism
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to redox biology and a substrate for sirtuins (SIRT1–7), PARPs, and CD38. The buffered form maintains stability at physiological pH for cell-culture supplementation.

## Common in-vitro applications
### Sirtuin activation studies
SIRT1/SIRT3 deacetylase activity assays + downstream substrate (FOXO, p53) acetylation Westerns.
Working range: `100 µM to 1 mM`

### PARP-1 activity modulation
DNA-damage models with PARP-1 cleavage / NAD+ depletion readouts.
Working range: `50 µM to 500 µM`

### Redox state measurement
NAD+/NADH ratio quantification in mitochondrial respiration assays.
Working range: `100 µM to 2 mM`

## Researchers commonly co-treat with
- **MOTS-c** — Parallel mitochondrial-energetics readouts.
- **Resveratrol / NMN** — Sirtuin-pathway agonist comparators.

## Storage and handling
- Lyophilized: −20°C or below, desiccated
- Reconstituted: 2–8°C, use within 14 days (NAD+ oxidizes in solution)
- Light + air: Protect from light and air
- Solubility: Soluble in bacteriostatic water; prepare fresh aliquots for each experiment

## Selected peer-reviewed citations
- Houtkooper RH, et al. (2012). NAD+ in cellular metabolism and disease. *Endocrine Reviews*.
- Imai S, Guarente L (2014). NAD+ and sirtuins in aging. *Trends in Cell Biology*.

## Verification
- Independently re-tested at Janoshik Analytical (HPLC-UV at 214 nm + ESI mass spectrometry).
- 100% purity-replacement guarantee: any batch failing an independent retest gets reshipped free.
- Per-batch QR code on the outer kit card resolves to https://aurex.bio/research/batch/[id].

## Compliance
Aurex is a chemical supplier and is **not** a compounding pharmacy or an outsourcing facility as defined under the Federal Food, Drug, and Cosmetic Act. Aurex products are not pharmaceuticals, food additives, or dietary supplements. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Distributed strictly for in-vitro laboratory research by qualified researchers 21+. Not for human or veterinary use. Not FDA approved.

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