# Semax 10mg

> ACTH-derived neuropeptide.

Canonical PDP: https://aurex.bio/products/semax-10mg
Research-data API: https://aurex.bio/api/research-data/semax-10mg

## Catalog facts
- Name: Semax
- SKU: `XA10`
- Category: cognitive
- Dosage: 10mg
- Vials per kit: 1
- Total mass: 10mg
- Half-life: ~20-30 minutes (intranasal)
- Reconstitution: 2ml bacteriostatic water → 5mg/ml

## Pricing
- One-time: $35 (MSRP $49.97 · list $39.97)
- Subscribe & save: $31.50
- Stack-tier floor (3+ vials in cart): $28
- Crypto checkout (BTC, ETH, USDC, USDT, LTC): -8% across cart
- Free tracked US shipping at $200+ subtotal, otherwise $18 flat

## Stock
- Current: 10 vials

## Pitch
Russian-origin synthetic ACTH(4-10) analog. Researched for BDNF expression, cognitive resilience, and neuroprotective signaling pathways.

## Mechanism
Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4-7) modified with a Pro-Gly-Pro extension. In vitro it modulates BDNF/NGF expression and has nootropic activity in cortical neuron cultures.

## Common in-vitro applications
### BDNF / NGF expression
qPCR + ELISA assays in primary cortical neuron cultures.
Working range: `100 nM to 10 µM`

### Glutamate receptor modulation
AMPA/NMDA receptor sensitivity assays in hippocampal slice preparations.
Working range: `1 µM to 100 µM`

## Researchers commonly co-treat with
- **Selank** — Adjacent ACTH-derived nootropic peptide with anxiolytic profile.
- **Cerebrolysin** — Comparator for neurotrophic-factor upregulation studies.

## Storage and handling
- Lyophilized: −20°C or below, desiccated
- Reconstituted: 2–8°C, use within 30 days
- Light + air: Protect from light and air
- Solubility: Soluble in bacteriostatic water (0.9% benzyl alcohol)

## Selected peer-reviewed citations
- Dolotov OV, et al. (2006). Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression. *Journal of Neurochemistry*.

## Bundled in research stacks
- [The Cognitive Stack](https://aurex.bio/stacks/cognitive-stack) — $139.97

## Verification
- Independently re-tested at Janoshik Analytical (HPLC-UV at 214 nm + ESI mass spectrometry).
- 100% purity-replacement guarantee: any batch failing an independent retest gets reshipped free.
- Per-batch QR code on the outer kit card resolves to https://aurex.bio/research/batch/[id].

## Compliance
Aurex is a chemical supplier and is **not** a compounding pharmacy or an outsourcing facility as defined under the Federal Food, Drug, and Cosmetic Act. Aurex products are not pharmaceuticals, food additives, or dietary supplements. Aurex does not provide dosage or use guidance — Federal regulations governing research-chemical distribution prohibit it. Distributed strictly for in-vitro laboratory research by qualified researchers 21+. Not for human or veterinary use. Not FDA approved.

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