Growth hormone axis (GH → IGF-1)

Hypothalamic-pituitary-liver axis regulating somatic growth and metabolism.

The GH axis begins with GHRH (growth hormone-releasing hormone) stimulating pituitary somatotrophs to secrete GH. GH then stimulates hepatic IGF-1 production, which mediates most of GH's growth-promoting effects. Peptides targeting this axis include: - CJC-1295 (GHRH analog) → stimulates GHRH-R - Ipamorelin (GHSR/ghrelin agonist) → stimulates GHSR - Together they activate complementary GH-secretion pathways Downstream, IGF-1 LR3 bypasses the axis entirely, providing direct IGF-1R activation with enhanced bioavailability.

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