BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids. Originally derived from a protective protein found in human gastric juice, BPC-157 has been the subject of extensive research into tissue regeneration, angiogenesis, and connective tissue healing since the 1990s.
Chemical Profile
| CAS Number | 137525-51-0 |
|---|---|
| Molecular Formula | C₆₂H₉₈N₁₆O₂₂ |
| Molecular Weight | 1419.5 g/mol |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Appearance | Lyophilized white powder |
| Purity (Aurex) | ≥99% (HPLC) |
Mechanism of Action
BPC-157 appears to modulate the nitric oxide (NO) pathway, upregulating eNOS expression and promoting angiogenesis — the formation of new blood vessels. This vascular response is thought to underlie its observed effects in wound healing and tissue repair models. Additionally, research suggests BPC-157 interacts with the VEGF pathway and may influence collagen organization in tendon and ligament models.
Research Applications
- Tendon-to-bone insertion healing in rat Achilles models
- Angiogenesis and vascular endothelial growth factor (VEGF) studies
- Gastric mucosal integrity and ulcer protection research
- Ligament fibroblast proliferation and collagen production
- Nitric oxide pathway modulation studies
- Connective tissue extracellular matrix organization
Storage & Handling
Store lyophilized BPC-157 at -20°C. Reconstitute with bacteriostatic water. Once in solution, refrigerate at 2–8°C and use within 2–4 weeks. BPC-157 is known to be stable in solution but should not be subjected to repeated freeze-thaw cycles.