Cognitive & Neuroprotection Research

Cognitive peptide research focuses on compounds that modulate neuronal function through multiple mechanisms:

**Semax** is a synthetic heptapeptide derived from ACTH(4–7) with a Pro-Gly-Pro stabilizing tail. It upregulates BDNF and trkB expression in primary cortical neuron cultures (100 nM–10 µM) and modulates glutamate receptor sensitivity in hippocampal slice preparations.

**Selank** is a tuftsin analog with a Pro-Gly-Pro extension. It modulates GABA-A receptor sensitivity and suppresses IL-6 / TNF-α in stimulated PBMC cultures. Its anxiolytic profile complements Semax's nootropic activity.

Both peptides are administered intranasally in research models, bypassing the blood-brain barrier. This route is particularly relevant for CNS-targeting peptides that would otherwise have poor CNS penetration.

Standard assays include BDNF qPCR/ELISA in cortical neurons, AMPA/NMDA electrophysiology in hippocampal slices, and cytokine panels in stimulated immune cells.

Aurex cognitive peptides are verified for purity (≥99%) and identity before release.