Aesthetic & Dermal Research

Aesthetic peptide research examines compounds that influence dermal and pigment biology:

**GHK-Cu** is the copper(II) complex of the endogenous tripeptide glycyl-L-histidyl-L-lysine. In vitro it modulates ~4,000 human genes toward a regenerative profile in cultured fibroblasts. Specific effects include: - Collagen-I, collagen-III, and decorin upregulation (1 nM–10 µM) - VEGF and FGF-2 release (angiogenesis) - Hair follicle dermal papilla proliferation (0.1–10 µM)

**PT-141 (Bremelanotide)** is a cyclic heptapeptide with sub-nanomolar affinity for MC3R and MC4R melanocortin receptors. Selectivity profiling across MC1R–MC5R distinguishes it from non-selective melanocortin agonists.

GHK-Cu solutions exhibit a characteristic deep blue color from the Cu(II) chromophore and are photosensitive — amber vials and light protection are required for reconstituted solutions.

Both compounds are independently verified by Janoshik for purity (≥99%) and identity before release.