IGF-1 LR3 1mg

IGF-1 LR3 is a recombinant analog of insulin-like growth factor 1 with an N-terminal extension and an arginine substitution at position 3. The modifications dramatically reduce IGFBP binding, increasing in-vitro receptor availability and prolonging effective half-life.

• IGF-1 receptor signaling
  IGF-1R phosphorylation + downstream PI3K/AKT pathway activation in C2C12 and primary myoblasts.
  Working range: 10 ng/mL to 100 ng/mL
• IGFBP-independent activity
  Comparative binding assays vs native IGF-1 in IGFBP-rich serum models.
  Working range: 1 ng/mL to 100 ng/mL
• Myoblast differentiation
  Myotube formation kinetics + MyoD/MyoG expression in C2C12 cultures.
  Working range: 5 ng/mL to 50 ng/mL

Background: [[lyophilization]] · [[reconstitution]]

• CJC-1295/Ipamorelin
  Upstream GH-axis activation — paired evaluation of GH→IGF-1 pathway.
• PEG-MGF
  Mechanistic comparator — splice variant of IGF-1 with different receptor kinetics.

1. Tomas FM, et al. (1993). Long-R3-IGF-I biological activity. Journal of Endocrinology.
2. Adams GR (2002). Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation. Journal of Applied Physiology.