Glow

GLOW is a research-grade blend of Tirzepatide (dual GLP-1/GIP agonist, 5 mg/mL) + Retatrutide (triple GLP-1/GIP/glucagon agonist, 4 mg/mL). The combination spans the full incretin-receptor axis plus glucagon-receptor signaling, with characterized bias profiles distinct from either compound alone in cAMP-accumulation panels.

• Multi-receptor incretin signaling
  Simultaneous GLP-1R / GIPR / GCGR cAMP profiling in CHO cells stably expressing each receptor.
  Working range: pM to nM range
• Hepatic glucagon-axis activation
  GCGR-mediated cAMP + downstream gluconeogenic gene expression in HepG2 cells.
  Working range: 10 nM to 1 µM
• Comparative bias profiling
  β-arrestin vs G-protein recruitment ratios across the receptor panel — blend vs single-agonist baselines.
  Working range: nM range

Background: [[lyophilization]] · [[reconstitution]]

• Tirzepatide (mono)
  Dual-agonist baseline for separating GIP-arm vs glucagon-arm contributions.
• Retatrutide (mono)
  Triple-agonist baseline — already in the Aurex catalog as standalone SKU.
• KLOW
  Sister blend (sema + cagri) with amylin-pathway addition — full Aurex blend comparator series.

1. Coskun T, et al. (2018). LY3298176, a novel dual GIP and GLP-1 receptor agonist (Tirzepatide). Molecular Metabolism.
2. Coskun T, et al. (2022). LY3437943, a novel triple GIP/GLP-1/glucagon receptor agonist (Retatrutide). Cell Metabolism.
3. Jastreboff AM, et al. (2023). Triple-Hormone-Receptor Agonist Retatrutide for Obesity. New England Journal of Medicine.