MOTS-c 40mg

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene. In vitro it activates AMPK signaling and translocates to the nucleus under metabolic stress to regulate adaptive nuclear gene expression.

• AMPK pathway activation
  Phospho-AMPK Western blot assays in C2C12 myotubes and HepG2 cells.
  Working range: 0.5 µM to 10 µM
• Insulin sensitivity modeling
  GLUT4 translocation + 2-deoxyglucose uptake in insulin-resistant cell models.
  Working range: 1 µM to 5 µM
• Mitochondrial biogenesis
  PGC-1α expression + mitochondrial copy-number quantification.
  Working range: 1 µM to 10 µM

Background: [[lyophilization]] · [[reconstitution]]

• NAD+ / nicotinamide riboside
  Parallel evaluation of mitochondrial-energetics readouts.
• SS-31 (Elamipretide)
  Distinct mitochondrial-targeting mechanisms — useful comparator in respiration assays.

1. Lee C, et al. (2015). The mitochondrial-derived peptide MOTS-c regulates metabolic homeostasis. Cell Metabolism.
2. Kim KH, et al. (2018). The mitochondrial-derived peptide MOTS-c translocates to the nucleus. Cell Metabolism.