MOTS-c 40mg

Mechanism

MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene. In vitro it activates AMPK signaling and translocates to the nucleus under metabolic stress to regulate adaptive nuclear gene expression.

In-vitro applications

• AMPK pathway activation
  Phospho-AMPK Western blot assays in C2C12 myotubes and HepG2 cells.
  Working range: 0.5 µM to 10 µM
• Insulin sensitivity modeling
  GLUT4 translocation + 2-deoxyglucose uptake in insulin-resistant cell models.
  Working range: 1 µM to 5 µM
• Mitochondrial biogenesis
  PGC-1α expression + mitochondrial copy-number quantification.
  Working range: 1 µM to 10 µM

Researchers commonly co-treat with

• [[NAD+ / nicotinamide riboside]] — Parallel evaluation of mitochondrial-energetics readouts.
• SS-31 (Elamipretide) — Distinct mitochondrial-targeting mechanisms — useful comparator in respiration assays.

Storage and handling

• · Lyophilized: −20°C or below, desiccated
• · Reconstituted: 2–8°C, use within 30 days
• · Light + air: Protect from light and air
• · Solubility: Soluble in bacteriostatic water (0.9% benzyl alcohol)

See also: [[lyophilization]] · [[reconstitution]]

Selected peer-reviewed citations

1. Lee C, et al. (2015). The mitochondrial-derived peptide MOTS-c regulates metabolic homeostasis. Cell Metabolism.
2. Kim KH, et al. (2018). The mitochondrial-derived peptide MOTS-c translocates to the nucleus. Cell Metabolism.

Bundled in stacks

• · [[The Longevity Stack]] — $329.97
• · [[The Flagship — Aurex Elite]] — $1,299.97